Daria
Tracy Grandstaff
Daria Morgendorffer (voice)
Wendy Hoopes
Jane Lane / Quinn Morgendorffer / Helen Morgendorffer (voice)
Julián Rebolledo
Jake Morgendorffer (voice)
Marc Thompson
Kevin Thompson (voice)
Alvaro J. Gonzalez
Trent Lane (voice)
Jessica Cydnee Jackson
Jodie Landon (voice)
Janie Mertz
Brittany Taylor / Sandi Griffin (voice)
Geoffrey Arend
Charles "Upchuck" Ruttheimer III (voice)
Sarah Drew
Stacy Rowe (voice)
John Worth Lynn, Jr.
Sick, Sad World's Announcer (voice)
Ashley Albert
Tiffany Blum-Deckler (voice)
Wes Spencer
Dog (voice)